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Columbia University Medical Center

Surplus of serotonin receptors may explain failure of antidepressants in some patients

Published in Mental Health Weekly Digest, January 25th, 2010

An excess of one type of serotonin receptor in the center of the brain may explain why antidepressants fail to relieve symptoms of depression for 50 percent of patients, a new study from researchers at Columbia University Medical Center shows.

The study in a mouse model is the first to find a causal link between receptor number and antidepressant treatment and may lead to more personalized treatment for depression, including treatments for patients who do not respond to antidepressants and ways to identify these patients before they undergo costly, and ultimately, futile therapies.

The research, led by Rene Hen, PhD, professor of pharmacology in the...

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