Drug Resistance
IL-13 Receptor Alpha 1 Gene Upregulated in Cisplatin Resistant Cells
Published in Monoclonal Antibodies Weekly, January 19th, 2000
"Human cancer cells have been found to express a large number of IL-13 receptors," wrote T. Ise and colleagues from the University of Occupational & Environmental Health, School of Medicine, Japan. "We have previously shown that mRNA encoding one of these receptors, IL-13R alpha 1, is increased in cisplatin-resistant cells and is upregulated in tumor cells cultured with cisplatin."
In order to understand the molecular mechanism of IL-13R alpha 1 gene expression, the researchers cloned approximately 52 kbp of the IL-13R...
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