Animal Models
Amyloid Precursor Protein Alters Hypoxic Recovery
Published in Neurological Diseases and Disorders Weekly, August 16th, 1999
O. Ghribi and colleagues from the University of Quebec, Canada, investigated the possible involvement of beta-amyloid (AP) in disrupting neuronal function during ischemia. Results were published in the journal Hippocampus ("Hypoxia-Induced Loss of Synaptic Transmission is Exacerbated in Hippocampal Slices of Transgenic Mice Expressing C-Terminal Fragments of Alzheimer Amyloid Precursor Protein," Hippocampus, 1999;9(3):201-205).
"We examined whether overexpression of C-terminal fragments of beta-amyloid precursor protein...
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