Genetics
Missense Mutation Animal Model Furthers AD Studies
Published in Neurological Diseases and Disorders Weekly, August 16th, 1999
Y. Nakano and colleagues from the Osaka University School of Medicine, Japan, established an animal model with a missense mutation of presenilin-1 (PS1) as an initial step toward understanding the molecular pathogenesis of familial Alzheimer's disease (FAD) and developing therapeutic strategies for the disease.
The data was published in a recent issue of the European Journal of Neuroscience ("Accumulation of Murine Amyloid Beta 42 in a Gene-Dosage-Dependent Manner in PS1 'Knock-In' Mice," European Journal of Neuroscience, July...
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