Published in Neurological Diseases and Disorders Weekly, August 16th, 1999
Y. Nakano and colleagues from the Osaka University School of Medicine, Japan, established an animal model with a missense mutation of presenilin-1 (PS1) as an initial step toward understanding the molecular pathogenesis of familial Alzheimer's disease (FAD) and developing therapeutic strategies for the disease.
The data was published in a recent issue of the European Journal of Neuroscience ("Accumulation of Murine Amyloid Beta 42 in a Gene-Dosage-Dependent Manner in PS1 'Knock-In' Mice," European Journal of Neuroscience, July...
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