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Novel Therapeutics

Estrogen Neuroprotection Independent of Hormonal Action

Published in Neurological Diseases and Disorders Weekly, August 16th, 1999

Estrogen's neuroprotective effect is independent of its hormonal activity.

The finding paves the way for the creation of new drugs for Alzheimer's disease (AD) and other diseases in which oxidative neuronal cell death occurs.

"These results ... may open the door toward the rational design of neuroprotective antioxidants with decreased hormonal side effects," suggested Bernd Moosmann and Christian Behl of the Max Planck Institute of Psychiatry, Munich, Germany.

Moosmann and Behl reported their findings in the Proceedings of the National Academy of Sciences ("The Antioxidant Neuroprotective Effects of Estrogens and Phenolic...

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