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Parkinson's Disease

Engineered Astrocytes Show Promise as Therapy

Published in Neurological Diseases and Disorders Weekly, August 16th, 1999

Engineered astrocytes expressing a tyrosine hydroxylase (TH) transgene show promise as therapy for Parkinson's disease (PD).

F. Trejo and colleagues from IPN, Mexico City, Mexico, further investigated the use of genetically engineered astrocytes as tools for the treatment of PD ("Biosynthetic Capacity of C6 Cells Engineered with a Glial Fibrillary Acidic Protein-Tyrosine Hydroxylase Transgene," Medical Science Research, June 1999;27(6):423-425).

"We previously reported that C6 glioma cells expressing a TH transgene induce behavioral recovery in a rat model of PD, but we did not directly demonstrate the production of either...

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