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Ion Channels

Rotational Motion Detected in Gates Controlling Nerve Impulses

Published in Neurological Diseases and Disorders Weekly, January 13th, 2000

Scientists who performed the first direct measurement of voltage-induced distance changes in ion channels - critical components of the nervous system - have reached a surprising conclusion.

As reported in the December16, 1999, issue of Nature, the amino acids in the voltage sensor move like keys turning in locks, not like the simple plungers that were predicted by current models.

"Within nerve cell membranes, there are special pores - or channels - that regulate the flow of sodium and potassium ions," said Paul Selvin, a professor of physics at the University of Illinois. "The channels open and close like little gates, depending on the voltage...

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