Published in Neurological Diseases and Disorders Weekly, June 1st, 2000
The discovery, reported in the May 18, 2000, issue of the journal Nature, proposes a common mechanistic link between the brain cell injury associated with Alzheimer's disease (AD) and known causes of neurotoxic damage, including oxidative stress, excitotoxic chemicals, and oxygen starvation.
Howard Hughes Medical Institute investigator Li-Huei Tsai and colleagues at Harvard Medical School suggest that the enzyme calpain could be a target for drugs designed to slow or stop the progression of brain damage caused by AD. ...
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