U.S. Food & Drug Administration

Uptake of botulinum neurotoxin into cultured neurons explored

Published in Nursing Home and Elder Business Week, March 21st, 2004

Scientists report results of investigations of uptake of botulinum neurotoxin into cultured neurons in a recent issue of the journal Biochemistry.

According to a study from the United States, "Botulinum neurotoxins (BoNTs) act within the synaptic terminal to block neurotransmitter release. The toxin enters the neuron by binding to neuronal membrane receptors, being taken up into an endosome-like compartment, and penetrating the endosome membrane via a pH-dependent translocation process. Once within the synaptic cytoplasm, BoNT serotypes A and E cleave separate sites on the C-terminus of the neuronal protein SNAP-25, one of the SNARE proteins required for synaptic...

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Source: Nursing Home and Elder Business Week (2004-03-21)

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