St. Antoine Hospital, Paris
Disrupted STAT3 signaling opens the door to tumor cell invasion
Published in Nursing Home and Elder Business Week, July 4th, 2004
"STAT3 is frequently overexpressed and constitutively activated by tyrosine phosphorylation during malignant transformation. Despite the clear importance of STAT3 in cell proliferation and survival in diverse human cancers, its possible contribution to tumor cell adhesion, motility and invasion remains hypothetical. We therefore compared the transforming properties of STAT3wt, its constitutively activated dimeric form STAT3C, and the dominant negative mutant STAT3-Y705F in human colorectal HCT8/S11 cancer cells," scientists in France report.
"Both STAT3wt and STAT3C exert a permissive...
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