Virginia Commonwealth University
Novel transplatinum drug ATZ interferes with topoisomerase I in cancer cells
Published in Nursing Home and Elder Business Week, November 14th, 2004
According to published research from the United States, "Cisplatin, cis-[PtCl2(NH3)(2)], is commonly utilized in various combination chemotherapy protocols for the treatment of both ovarian and breast cancer while the corresponding trans isomer is therapeutically inactive.
"This work describes efforts to elucidate the cellular mechanism of action of a novel trans-platinum compound, trans-(dichloroamminethiazole)platinum(H) (ATZ), which demonstrates antiproliferative and cytotoxic effects against both MCF-7 human breast and A2780 human ovarian...
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