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Columbia University, New York

Photo-oxidative events elicit threats to retinal pigment epithelial cells

Published in Nursing Home and Elder Business Week, June 19th, 2005

Photo-oxidative events elicit threats to retinal pigment epithelial cells.

"Pathological features of age-related macular degeneration such as the formation of extracellular deposits and neovascularization are frequently viewed as outcomes of compromising processes within retinal pigment epithelial cells, but the initiating circumstances are poorly understood," according to scientists in the United States.

"Here, we tested the hypothesis that photo-oxidation events initiated by A2E, a blue light-excitable aging fluorophore of the retinal pigment epithelium, can set the stage for altered cellular signaling and changes in the expression of genes that...

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