University of Michigan

Cellular immortalization is associated with concordant copy number and transcriptional activity

Published in Nursing Home and Elder Business Week, March 12th, 2006

A study from the United States has detailed the concordant copy number and transcriptional activity of genes mapping to derivative chromosomes 8 during cellular immortalization in vitro.

"Deletion, rearrangement, or amplification of sequences mapping to chromosome 8 are frequently observed in human prostate and other tumors. However, it is not clear whether these events alter the transcriptional activity of the affected genes."

"To examine this question," wrote L. Begley and colleagues, University of Michigan, "we have utilized oligonucleotide microarray technology and compared the transcriptional patterns of normal human prostate tissues and five...

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Source: Nursing Home and Elder Business Week (2006-03-12)

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