Alzheimer Disease
Studies from Osaka University have provided new data on alzheimer disease
Published in Nursing Home and Elder Business Week, December 3rd, 2006
A new study, "Real-time and single fibril observation of the formation of amyloid beta spherulitic structures," is now available. "In Alzheimer disease, amyloid beta, a 39-43-residue peptide produced by cleavage from a large amyloid precursor protein, undergoes conformational change to form amyloid fibrils and deposits as senile amyloid plaques in the extracellular cerebral cortices of the brain. However, the mechanism of how the intrinsically linear amyloid fibrils form spherical senile plaques is unknown," scientists writing in the Journal of Biological Chemistry report.
"With total internal reflection fluorescence microscopy combined with the use of thioflavin...
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