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Aging

Research on aging reported by scientists at Northwestern University

Published in Nursing Home and Elder Business Week, August 9th, 2009

According to a study from the United States, "Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits were exposed in a subset (30%) of middle-aged mice that performed below criterion on a hippocampal-dependent contextual fear conditioning task."

"Basal neuronal excitability was comparable in middle-aged and young mice, but learning-related modulation of the post-burst afterhyperpolarization (AHP)-a general mechanism engaged during learning-was impaired in CA1 neurons from middle-aged weak learners. Thus, modulation of neuronal excitability is critical for retention of context fear in middle-aged mice," wrote C.C. Kaczorowski and...

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