Age and Aging

Research on age and aging reported by S.K. Mak et al

Published in Nursing Home and Elder Business Week, February 7th, 2010

"Because of its normal function in synaptic plasticity and pathologic involvement in age-related neurodegenerative diseases, the protein alpha-synuclein could play an important role in aging processes. Here we compared alpha-synuclein expression in the substantia nigra and other brain regions of young (2-month-old), middle-aged (10-month-old), and old (20-month-old) mice," investigators in the United States report.

"Levels of nigral alpha-synuclein mRNA, as assessed by both in situ hybridization and qPCR, were high in young mice and progressively declined in middle-aged and old animals. This age-dependent mRNA loss was paralleled by a marked reduction of alpha-synuclein...

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Source: Nursing Home and Elder Business Week (2010-02-07)

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