Preeclampsia
Angiogenesis can't compensate for placental arterial changes at high altitudes
Published in OBGYN and Reproduction Week, June 23rd, 2003
"Uterine blood flow and birth weight are reduced and the risk of pre-eclampsia is increased in high-altitude pregnancies. Since IUGR and pre-eclampsia are associated with reduced invasion and remodeling of maternal spiral arteries we asked whether the terminal ends of uteroplacental arteries located at the maternal-fetal decidual interface evidenced less remodeling in 19 high (3100 m) compared with 13 moderate (1600 m) altitude placentae from normal pregnancies. Previous work has demonstrated marked villous angiogenesis in high altitude placentae," scientists in the United States...
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