OBGYN & Reproduction Week
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Fancomi Anemia
IVF, PGD used to produce sibling stem-cell donor
March 15th, 2004
IVF and PGD has been successfully used to produce an HLA-matched sibling donor for a Fancomi anemia patient. "The only proven cure for Fanconi anemia (FA)-associated bone marrow failure is successful allogeneic hematopoietic stem-cell transplantation (HSCT)," hematologists in the United States explained. "However, HSCT with donors other than HLA-identical siblings is associated with high morbidity and poor survival." "Therefore," S.S. Grewal and colleagues at the University of Minnesota "used preimplantation genetic diagnosis (PGD) to select an embryo produced by in vitro fertilization (IVF) that was unaffected by FA and was HLA-identical to the...
Source: OBGYN & Reproduction Week (2004-03-15)
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