OBGYN & Reproduction Week
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Obstetrics
COX-2 preferential inhibitors should be used with caution during pregnancy
March 15th, 2004
COX-2 preferential inhibitors should be used with caution during pregnancy. According to a study from Switzerland, "tocolysis with nonsteroidal anti-inflammatory drugs (NSAIDs) has been widely accepted for several years. Recently, the use of the cyclooxygenase-2 (COX2) preferential NSAID nimesulide has been proposed. However, data reporting neonatal acute renal failure or irreversible end-stage renal failure after maternal ingestion of nimesulide question the safety of this drug for the fetus and the neonate." "Therefore, this study was designed to define the renal effects of nimesulide in newborn rabbits. Experiments were performed in 28 newborn...
Source: OBGYN & Reproduction Week (2004-03-15)
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