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OBGYN & Reproduction Week

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Obstetrics



Lamotrigine metabolism changes as pregnancy progresses



March 15th, 2004

Lamotrigine metabolism changes as pregnancy progresses.

"This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly," reported researchers in the United States.

"LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters," said P.B. Pennell and colleagues, Emory University, School of Medicine.

"LTG clearance progressively increased until 32...


Source: OBGYN & Reproduction Week (2004-03-15)

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