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Uterine Leiomyoma

Protective effects of progesterone receptor modulator CDB-2914 described

Published in OBGYN and Reproduction Week, April 18th, 2005

Scientists in Japan conducted a study "to evaluate the effects of the progesterone receptor modulator CDB-2914 on proliferative activity and apoptosis in cultured human uterine leiomyoma cells."

Describing their work, Q. Xu and colleagues, Kobe University, explained, "Isolated leiomyoma cells were subcultured in phenol red-free DMEM supplemented with 10% fetal bovine serum for 120 hours and then stepped down to serum-free conditions for 12, 24, 48, and 96 hours in the absence or presence of graded concentrations of CDB-2914 (10-9), 10-8, 10-7, and 10-6 M).

"The number of viable cultured leiomyoma cells was...

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