Nociception

Chronic estrogen sensitizes mechanosensitive afferents innervating cervix

Published in OBGYN and Reproduction Week, May 23rd, 2005

According to a report by Wake Forest University anesthesiologists, "Estrogen increases reflex nocifensive responses to distension of the uterus and the urinary bladder, but estrogen's effects on afferent response to distension of the uterine cervix, the site of obstetric and some gynecologic pain, has not been studied."

In their study, the researchers analyzed "simile fiber recording of hypogastric nerve responses to uterine cervical distension ...from ovariectomized (OVX) rats and OVX rats treated with estrogen (ES)."

"Spontaneous activity was greater in the ES group (13 of 24 units; 54%) than in the OVX group (6 of 27 units; 22%)," said B.G. Liu...

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Source: OBGYN and Reproduction Week (2005-05-23)

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