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Endocrinology
Insulin-like growth factor deficiency retards intrauterine and postnatal growth
July 4th, 2005
Insulin-like growth factor deficiency retards intrauterine and postnatal growth. "Insulin-like growth factor I (IGF-I) is a key factor in intrauterine development and postnatal growth and metabolism. The secretion of IGF-I in utero is not dependent on growth hormone (GH), whereas in childhood and adult life, IGF-I secretion seems to be mainly controlled by GH, as revealed from studies on patients with GHRH receptor and GH receptor mutations," investigators in Netherlands report. "In a 55-yr-old male, the first child of consanguineous parents, presenting with severe intrauterine and postnatal growth retardation, microcephaly, and sensorineural...
Source: OBGYN & Reproduction Week (2005-07-04)
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