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Gynecology

Circulating VEGF correlates with ovarian cancer progression in study models

"Vascular endothelial growth factor (VEGF) performs as an angiogenic and permeability factor in ovarian cancer, and its overexpression has been associated with poor prognosis. However, models to study its role as a marker of tumor progression are lacking," scientists in Italy report.

"We generated xenograft variants derived from the A2780 human ovarian carcinoma (1A9), stably transfected with VEGF₁₂₁ in sense (1A9-VS-1) and antisense orientation (1A9-VAS-3). 1A9, 1A9-VS-1, and 1A9-VAS-3 disseminated in the peritoneal cavity of nude mice, but only 1A9-VS-1, the...

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