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Neuroprotection
Neural tube defects examined, peptide-mediated protection revealed
July 4th, 2005
A study from the United States has reported on peptide-mediated protection from ethanol-induced neural tube defects. "Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion and prevent ethanol-induced growth retardation in mouse whole embryo culture. "Here we ask whether NAP and SAL also prevent ethanol-induced major malformations of the nervous system," wrote S.Y. Chen and colleagues,...
Source: OBGYN & Reproduction Week (2005-07-04)
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