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Analgesia
Efficacy of diphenhydramine-morphine mixture for intravenous PCA studied
July 4th, 2005
Anesthesiologists have evaluated the analgesic and dose-related antiemetic efficacy of a diphenhydramine-morphine mixture for intravenous patient-controlled analgesia (PCA) in women undergoing total hysterectomy. In the double-blinded, randomized, placebo-controlled study, "patients were randomly allocated to one of three groups (n=40 each). In group 1, patients received saline at induction and morphine 1 mg/ml alone for postoperative PCA. Patients in groups 2 and 3 received diphenhydramine 30 mg i.v. at induction and were given a 1.2:1 or a 4.8:1 ratio, respectively, of diphenhydramine-morphine mixture for postoperative PCA. A total of 112 patients completed the...
Source: OBGYN & Reproduction Week (2005-07-04)
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