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Apoptosis
Neuronal apoptosis examined, oxidative damage and defective DNA repair revealed
July 4th, 2005
A recent study from the United States has reported that oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice. "DNA repair plays a critical, but imprecisely defined role in neuronal survival during cortical neurogenesis. We examined cortical development in mice deficient for the DNA end-joining protein, Ku70," wrote R. Narasimhaiah and colleagues, Wesleyan University. "At gestational day 14.5, corresponding to the peak of neurogenesis, the Ku70(-/-) embryonic cerebral cortex displayed 25- to 30-fold more cell death than heterozygous littermates,...
Source: OBGYN & Reproduction Week (2005-07-04)
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