Transthyretin

Transthyretin studied, synthesis by subcommissural ependymal cells defined

Published in OBGYN and Reproduction Week, July 25th, 2005

A recent study from Chile has reported on the synthesis of transthyretin (TTR) by the ependymal cells of the subcommissural organ (SCO).

"TTR is a protein involved in the transport of thyroid hormones in blood and cerebrospinal fluid (CSF). The only known source of brain-produced TTR is the choroid plexus.

"In the present investigation," wrote H.A. Montecinos and colleagues, University Austral Chile, "we have identified the SCO as a new source of brain TTR. The SCO is an ependymal gland that secretes glycoproteins into the CSF, where they aggregate to form Reissner fiber (RF).

"Evidence exists that the SCO also secretes proteins...

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Source: OBGYN and Reproduction Week (2005-07-25)

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