Embryonic Mutation
Hypomorphic mutation in hnRNP U results in postimplantation lethality
Published in OBGYN and Reproduction Week, September 12th, 2005
According to recent research from the United States, "The present study characterized an embryonic lethal mutation induced by insertion of the U3Neo gene trap retrovirus into an intron of the gene encoding heterogeneous ribonuclear protein U (Hnrnpu), which maps to the distal arm of mouse chromosome 1. Murine hnRNP U was found to be identical to the human protein at all but one of 341 amino acid residues."
"Embryos homozygous for the provirus showed obvious abnormalities after 6.5 days of development (E6.5) and were resorbed by E10.5.
"Expression of the...
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