Obstetrics
Decidual natural killer cells govern key functions at the human fetal-maternal interface
Published in OBGYN and Reproduction Week, November 6th, 2006
"Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells," researchers in Israel reported.
"However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and...
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