Cervical Cancer
Scientists at University of Lecce detail research in cervical cancer
Published in OBGYN and Reproduction Week, October 8th, 2007
According to a study from Lecce, Italy, "We report the cytotoxic effects obtained in HeLa cells of three newly synthesized platinum complexes containing both an O,O '-chelated acetylacetonate ligand and a sulfur ligand in the platinum coordination sphere, which show, by H-1 NMR, negligible reactivity with purine bases. These compounds induce cell death with [Pt(O,O '-acac)(gamma-acac)(DMS)] being the most effective (IC50 = 0.98 +/- 0.056 and 1.82 +/- 0.023 mc M for [Pt(O,O '-acac)(gamma-acac)(DMS)] and cisplatin, respectively)."
"About 50% of cells died after 5 h treatment with 100 mc M [Pt(O,O '-acac)(gamma-acac)(DMS)] whilst a 16 h incubation was required to get the...
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