Ovarian Cancer

Data from A.A. Ahmed and colleagues advance knowledge in ovarian cancer

Published in OBGYN and Reproduction Week, February 18th, 2008

According to a study from Cambridge, the United Kingdom, "The extracellular matrix (ECM) can induce chemotherapy resistance via AKT-mediated inhibition of apoptosis. Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic spindle abnormalities in ovarian cancer cells."

"Paclitaxel-resistant cells treated with recombinant TGFBI protein show integrin-dependent restoration of paclitaxel sensitivity via FAK- and Rho-dependent stabilization of microtubules. Immunohistochemical staining for TGFBI in paclitaxel-treated ovarian cancers from a prospective clinical trial...

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Source: OBGYN and Reproduction Week (2008-02-18)

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