Obesity, Fitness & Wellness Week
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Obesity
Data from GlaxoSmithKline, Department of Medicinal Chemistry advance knowledge in obesity
December 30th, 2006
Current study results from the report, "6-(4-chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist," have been published. "Genetic manipulation studies in mice at both the MCH receptor 1 (MCHR1) as well as the MCH peptide levels have implicated MCHR1 as a key player in energy homeostasis. The phenotype exhibited by these studies, that is, increased metabolic rate, resistance to high fat diet, and subsequent weight loss, has spurred considerable efforts to develop antagonists of MCHR1," scientists writing in the Journal of Medicinal Chemistry report. "In continuation of efforts directed toward this...
Source: Obesity, Fitness & Wellness Week (2006-12-30)
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