Obesity, Fitness & Wellness Week
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Obesity
Researchers' work from GlaxoSmithKline, Department of Medicinal Chemistry focuses on obesity
December 30th, 2006
Scientists discuss in "Potent, selective, and orally efficacious antagonists of melanin-concentrating hormone receptor 1" new findings in obesity. According to recent research from the United States, "The high expression of MCH in the hypothalamus with the lean hypophagic phenotype coupled with increased resting metabolic rate and resistance to high fat diet-induced obesity of MCH KO mice has spurred considerable efforts to develop small molecule MCHR1 antagonists. Starting from a lead thienopyrimidinone series, structure-activity studies at the 3-and 6-positions of the thienopyrimidinone core afforded potent and selective MCHR1 antagonists with representative examples having suitable...
Source: Obesity, Fitness & Wellness Week (2006-12-30)
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