Women's Health

Insulin receptor expression decreases at high estradiol levels

Published in Obesity and Diabetes Week, January 27th, 2003

High levels of estradiol reduced expression of the insulin receptor while low doses of the hormone increased insulin receptor expression, indicating that higher dose hormonal contraceptives may promote insulin resistance in women.

"The role of 17-beta-estradiol in the early steps of insulin action is only partially known, although its effect on glucose homeostasis has been reported," wrote Celestino Gonzalez and colleagues at the University of Oviedo in Spain. "In this paper, we attempt to prove the influence of 17-beta-estradiol on the insulin receptor of ovariectomized rats treated with different hormonal doses."

The researchers reported, "Our...

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Source: Obesity and Diabetes Week (2003-01-27)

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