Obesity Pathogenesis

Acylation-stimulating protein deficiency induces obesity resistance in mice

Published in Obesity and Diabetes Week, February 3rd, 2003

"Acylation-stimulating protein (ASP) acts as a paracrine signal to increase triglyceride synthesis in adipocytes. ASP administration results in more rapid postprandial lipid clearance. In mice, C3 (the precursor to ASP) knockout results in ASP deficiency and leads to reduced body fat and leptin levels," researchers in Canada report.

"The protective potential of ASP deficiency against obesity and involvement of the leptin pathway were examined in ob/ob C3(-/-) double knockout mice (2KO)," reported Zhunan Xia and colleagues at McGill University Health Center. "Compared with age-matched ob/ob mice, 2KO mice had delayed postprandial triglyceride and fatty...

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Source: Obesity and Diabetes Week (2003-02-03)

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