Diabetes Pathogenesis

Mitochondrial reactive oxygen species reduce insulin secretion

Published in Obesity and Diabetes Week, March 3rd, 2003

"Pancreatic beta-cells exposed to hyperglycemia produce reactive oxygen species (ROS). Because beta-cells are sensitive to oxidative stress, excessive ROS may cause dysfunction of beta-cells. Here we demonstrate that mitochondrial ROS suppress glucose-induced insulin secretion (GIIS) from beta-cells," researchers in Japan report.

"Intracellular ROS increased 15 minutes after exposure to high glucose and this effect was blunted by inhibitors of the mitochondrial function," reported Koji Sakai and collaborators at Kumamoto University School of Medicine. "GIIS was also suppressed by H₂ O₂ , a chemical substitute for ROS. Interestingly, the...

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Source: Obesity and Diabetes Week (2003-03-03)

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