Diabetic Neuropathy

High glucose induces oxidative stress and mitochondrial dysfunction in neurons

Published in Obesity and Diabetes Week, March 3rd, 2003

According to recent research from the United States, "The current study examines the association between glucose induction of reactive oxygen species (ROS), mitochondrial (Mt) depolarization, and programmed cell death in primary neurons."

"In primary dorsal root ganglion (DRG) neurons, 45 mM glucose rapidly induces a peak rise in ROS corresponding to a 50% increase in mean Mt size at 6 hours (p<0.001)," reported James W. Russell and collaborators at the University of Michigan in Ann Arbor. "This is coupled with loss of regulation of the Mt membrane potential (Mt membrane hyperpolarization, followed by depolarization, MMD), partial depletion of ATP, and activation of...

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Source: Obesity and Diabetes Week (2003-03-03)

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