Type I Diabetes
Intramuscular gene transfer prevents autoimmune diabetes in mice
Published in Obesity and Diabetes Week, March 17th, 2003
According to recent research from Peoples Republic of China, "the imbalance of Th1/Th2 subsets is an important pathogenic mechanism for insulin-dependent diabetes mellitus (IDDM). Calcitonin gene-related peptide (CGRP) has been found to play important roles in the regulation of T lymphocytes. We hypothesize that exogenous CGRP administration during insulitis may modulate the balance of Th lymphocytes, thereby providing a therapeutic intervention for IDDM."
"We established CGRP gene transfer by naked plasmid injection into the skeletal muscles with electroporation enhancement. The...
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