Diabetes Pathogenesis
Thrombin-activatable fibrinolysis inhibitor implicated in vascular damage
Published in Obesity and Diabetes Week, March 31st, 2003
"Hypofibrinolysis is a common finding in patients with diabetes mellitus and a risk factor for diabetic nephropathy. Recently, a new potent inhibitor of fibrinolysis, the thrombin-activatable fibrinolysis inhibitor (TAFI), has been isolated from human plasma. The possibility that TAFI also participates in the mechanism of hypofibrinolysis has not been appraised in diabetic patients with microalbuminuria," researchers in Japan report.
"In the present study, we investigated the plasma levels of TAFI and...
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