Hyperglycemia
Reduction in beta-cells causes glucose intolerance or decompensated diabetes
Published in Obesity and Diabetes Week, March 31st, 2003
"We have proposed that hyperglycemia-induced dedifferentiation of beta-cells is a critical factor for the loss of insulin secretory function in diabetes. Here we examined the effects of the duration of hyperglycemia on gene expression in islets of partially pancreatectomized (Px) rats," researchers in the United States report.
"Islets were isolated, and mRNA was extracted from rats 4 and 14 weeks after Px or sham Px surgery," stated D. Ross Laybutt and collaborators at the Joslin Diabetes...
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