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Metabolism

Orexin A results in hypophagia induced by hyperthermia

Published in Obesity and Diabetes Week, March 31st, 2003

Orexin A exerted the paradoxical effect of hypophagia induced by hyperthermia in a rat study.

According to recent research from Italy, "This experiment tested the effect of the sympathetic and thermogenic activation induced by orexin A on eating behavior. The food intake, firing rate (FR) of the sympathetic nerves to interscapular brown adipose tissue (IBAT), MAT and abdominal temperatures (T-IBAT and T-ab), and heart rate (HR) were monitored in 24-hour-fasting male Sprague-Dawley rats for 15 hours after food presentation."

"Orexin A (1.5 nmol) was injected into the lateral cerebral ventricle 6 hours before food presentation while FR, T-IBAT, and...

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