Adiposity
Beta-3-adrenoceptor knockout in mice depresses brown adipocytes in white fat
Published in Obesity and Diabetes Week, April 7th, 2003
"White and brown adipocytes are usually located in distinct depots; however, in response to cold, brown adipocytes appear in white fat. This response is mediated by beta-adrenoceptors but there is a controversy about the subtype(s) involved. In the present study, we exposed to cold beta-3-adrenoceptor knockout mice (beta-3 KO) on a C57BL/6J genetic background and measured in white adipose tissue the density of multilocular cells and the expression of the brown adipocyte marker uncoupling protein-1 (UCP1)," researchers in Switzerland and Italy report.
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