Cardiac Hypertrophy
Dietary fat can alter PKC beta2 activation and exert mild hypertrophic effect
Published in Obesity and Diabetes Week, April 7th, 2003
According to recent research from the United States, "Signal transduction through protein kinase C (PKC) beta2 may modulate cardiac hypertrophy in pressure-overloaded rat myocardium. Because PKC beta2 can be activated by fatty acids and diacylglycerol, we hypothesized that altering the level and type of dietary fat might modulate cardiac PKC activation and stimulate hypertrophy in otherwise normal rat myocardium."
"Male Sprague-Dawley rats (n=32) were randomly assigned to either a low fat [10% total energy intake (TEI)] or high fat diet (40% TEI) based on corn or coconut...
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