Published in Obesity and Diabetes Week, April 14th, 2003
"We and others have suggested that insulin predominantly acts indirectly to inhibit hepatic glucose production (HGP) via suppression of gluconeogenic precursors, FFAs [free fatty acids], and glucagon.
"To test that hypothesis, we performed high-dose hyperinsulinemic-euglycemic clamps using [3-(3)H]-glucose in liver-specific insulin receptor knockout (LIRKO) mice, LIRKO mice treated with streptozotocin (LIRKO+STZ), and controls," wrote S.J. Fisher and colleagues, Joslin Diabetes Center, Boston, Massachusetts.
While fasting glucose...
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