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Physiology

Weight loss improves beta-cell function in severely obese women

Published in Obesity and Diabetes Week, April 14th, 2003

Weight loss in severely obese women results in improved beta-cell function when related to insulin sensitivity, study results show.

According to a report from Sweden, "Islet function was examined in 13 severely obese women (body mass index 46.4 ± 5.5 (SD) kg/m2) before and after standardized 15% and 25% weight reduction (WR) instituted by bariatric surgery."

"The insulin response to arginine at fasting (AIR(1)), at 14 mmol/l, and at > 25 mmol/l glucose was reduced by 37%-50% after 15% and 25% WR (p{{<=}}0.05)," reported M. Guldstrand and colleagues at Lund University.

"Insulin sensitivity was determined as...

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