Type 2 Diabetes
Opiate analgesics or prokinetic agents may alter glucose control
Published in Obesity and Diabetes Week, April 14th, 2003
S. Gonlachanvit and colleagues, Temple University, Pennsylvania, conducted a study "to determine the effects of altering gastric emptying on postprandial plasma glucose concentration after a physiologic meal in patients with type 2 diabetes mellitus [T2DM]."
The double-blind, three-way crossover study involved nine T2DM patients randomized to receive "erythromycin 200 mg, morphine 8 mg, or normal saline (placebo) intravenously prior to ingestion of a radiolabeled, dual-isotope, solid-liquid meal. Gastric emptying of solids and liquids and serial plasma...
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