Published in Obesity and Diabetes Week, April 21st, 2003
"To elucidate the function of PPAR-gamma in leptin-deficient mouse (ob/ob) liver, a PPAR-gamma liver-null mouse on an ob/ob background, ob/ob-PPAR-gamma(fl/fl)AlbCre+, was produced using a floxed PPAR-gamma allele, PPAR-gamma(fl/fl), and Cre recombinase under control of the albumin promoter (AlbCre). The liver of ob/ob-PPAR-gamma(fl/fl)AlbCre+ mice had a deletion of exon 2 and a corresponding loss of full-length PPAR-gamma mRNA and protein," investigators in the United States report.
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