Diabetes Pathogenesis
Disruption of PPAR-gamma in leptin-deficient mice improves fatty liver
Published in Obesity and Diabetes Week, April 21st, 2003
"To elucidate the function of PPAR-gamma in leptin-deficient mouse (ob/ob) liver, a PPAR-gamma liver-null mouse on an ob/ob background, ob/ob-PPAR-gamma(fl/fl)AlbCre+, was produced using a floxed PPAR-gamma allele, PPAR-gamma(fl/fl), and Cre recombinase under control of the albumin promoter (AlbCre). The liver of ob/ob-PPAR-gamma(fl/fl)AlbCre+ mice had a deletion of exon 2 and a corresponding loss of full-length PPAR-gamma mRNA and protein," investigators in the United States report.
...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Obesity and Diabetes Week
More Articles from Obesity and Diabetes Week
- Heart Disease Risk Factor
-374 T/A RAGE gene polymorphism associated with CVD in type 1 diabetic patients - Obesity Genomics and Genetics
Alpha/beta hydrolase2 gene is associated with obesity - Diabetes Pathogenesis
Insulin autoantibodies associated with islet inflammation in NOD congenic mice - Fat Metabolism
Fatty acid desaturase expression is regulated by vitamin A and retinoic acid - Obesity Therapy
Identifying overweight patients who most benefit by weight loss important - Type 2 Diabetes Therapy
Advances made in small molecule inhibitors of PTP1B for treating type 2 diabetes - More from this issue of Obesity and Diabetes Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
