Diabetes Pathogenesis
Oxidative stress leads to endothelial cell dysfunction in diabetes
Published in Obesity and Diabetes Week, April 28th, 2003
"Micro- and macrovascular complications are the leading causes of mortality in Types 1 and 2 diabetes. Hyperglycemia results in increased advanced glycosylation end (AGE) products, oxidative stress, increased sorbitol levels, and increased activation of protein kinase C. These effects of hyperglycemia eventually lead to impaired endothelium-dependent relaxation to vasoactive substances such as acetylcholine and bradykinin," researchers in Canada report.
"Increased oxidative stress, which will reduce levels of nitric oxide (NO), and/or decreased bioavailability of...
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