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Receptor Studies

Cannabinoid CB1 receptor antagonist increases Acrp30 mRNA expression

Published in Obesity and Diabetes Week, May 19th, 2003

The cannabinoid CB1 receptor antagonist SR141716 increased Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells.

According to published research from France, "This study investigates the effects of SR141716, a selective CB1 receptor antagonist that reduces food intake and body weight of rodents, on Acrp30 mRNA expression in adipose tissue. Acrp30, a plasma protein exclusively expressed and secreted by adipose tissue, has been shown to induce free fatty acid oxidation, hyperglycemia and hyperinsulinemia decrease, and body weight reduction."

"We report that...

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